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Gastrointestinal adverse effects have most generally consisted of completely dry mouth (30 %) and irregularity (15 %), stomach pain, anorexia, queasiness, puking, looseness of the bowels (1 %), parotitis, pseudo-obstruction (including colonic pseudo-obstruction), and also salivary gland pain. Nausea or vomiting (13.2 %) as well as vomiting (10.5 %) have actually been stated with epidural clonidine. [Ref]





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Genitourinary negative side effects have actually consisted of erectile dysfunction in male individuals (24 %), retrograde as well as delayed climaxing, as well as a lack of ability to achieve climax in women individuals. [Ref]





A 66-year-old lady with a record of psoriasis in remission created erythematous, scabby plaques on the extensor areas of her lower arms within three days after starting clonidine treatment for command of flushing. The author of this instance record suspected that clonidine might induce a fall in intracellular cAMP, leading to skin cell proliferation, and also, in some instances, a psoriasiform eruption. [Ref]





Dermatologic responses have been stated in 10 % to 38 % of individuals that make use of transdermal clonidine. These responses consist of psoriasis exacerbations, regional dermatitis and/or coloring, alopecia, angioneurotic edema, hives, pruritus, breakout, and urticaria. [Ref]





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Psychiatric negative side effects have actually included psychological ailment (5 %), aggressiveness (1 %), tearfulness (3 %) as well as uncommon reports of depression, which has actually been one of the most usual psychological response to clonidine. Rare situations of honest psychoses as well as delirium have been linked with clonidine withdrawal. Aberrations have actually been stated postmarketing. [Ref]

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